Comparing supplements by bottle size or “1,000 mg fish oil” can be misleading. The meaningful figures are the full daily EPA and DHA dose, oil form, added nutrients, number of capsules and authorized use.

The table below uses current Canadian EyeDropShop product information. Formulas can change, so confirm the label before purchasing.

Why PRN De3 earns the “top dry-eye omega” position

PRN De3 is not the winner of every possible category. It is the strongest all-around omega-3 choice in this group when the decision is based on a combination of high EPA+DHA dose, rTG form, dry-eye-specific clinical history, vitamin D3 and Health Canada-authorized MGD-related claims.

Its 1,680 mg EPA is higher than the compared omega products, and its combined 2,240 mg EPA+DHA is also the highest. The formula matches the dose used in published randomized dry-eye studies. These are substantive differences, not simply brand prestige.

PRN De3 vs I-VU Omega-3 Plus

Both use re-esterified triglyceride omega-3, which makes this the closest format comparison. I-VU provides 1,200 mg EPA, 600 mg DHA and 24 mg DPA in two capsules. PRN provides 480 mg more EPA, 40 mg less DHA and adds 1,000 IU vitamin D3 in three capsules.

Choose the conversation based on priorities. PRN has the larger EPA+DHA dose, the 3:1 profile and more directly product-matched dry-eye evidence. I-VU has a simpler two-capsule routine, includes DPA and may appeal to someone who already receives enough vitamin D elsewhere.

PRN De3 vs NutraSea Dry Eye

NutraSea uses triglyceride-form omega-3 with 1,200 mg EPA, 300 mg DHA and 150 mg GLA from evening primrose/borage sources. Its 4:1 EPA:DHA ratio is even more EPA-dominant than PRN, but the total EPA+DHA dose is lower and the serving is four softgels.

GLA makes NutraSea a different strategy, not a weaker copy. Someone seeking an omega-3-plus-GLA formula may prefer it. PRN remains the more concentrated EPA+DHA choice and includes D3 rather than GLA.

PRN De3 vs Systane Omega-3

Systane provides 400 mg EPA and 200 mg DHA per softgel, taken three times daily: 1,200 mg EPA plus 600 mg DHA. It uses triglyceride form and has Health Canada dry-eye wording on the Canadian product description.

PRN delivers 440 mg more combined EPA+DHA per day, uses rTG, has a higher EPA percentage and includes D3. Systane offers a clean two-ingredient marine-oil approach without added D3.

PRN De3 vs Blink NutriTears

Blink NutriTears is not an omega-3 competitor in the literal sense. Its one-softgel formula lists vitamin D, lutein, zeaxanthin and curcuminoids, but no EPA or DHA. It targets dry-eye nutrition through a different ingredient set and dramatically lower capsule burden.

For a shopper specifically seeking high-dose EPA/DHA, PRN is the clear fit. For someone unable or unwilling to take fish oil, Blink is a separate category worth discussing. Fish allergy still requires professional guidance; “fish-free” should be verified on the current label.

What about generic fish oil?

A generic can be high quality, but compare active ingredients. A label that says “1,000 mg fish oil” may provide only about 300 mg EPA+DHA. Matching PRN's 2,240 mg could require many capsules. Also check whether the oil is triglyceride, rTG or ethyl ester and whether independent purity data are available.

Price per bottle is therefore less informative than price per 1,000 mg EPA+DHA at the intended daily serving. Even then, a cheaper equivalent should match form, tolerability and quality—not just milligrams.

Which product is right for which priority?

• Highest combined EPA+DHA plus D3: PRN De3.
• Two-capsule rTG formula: I-VU Omega-3 Plus.
• Omega-3 plus GLA: NutraSea Dry Eye.
• Simple triglyceride EPA/DHA formula: Systane Omega-3.
• One capsule without listed EPA/DHA: Blink NutriTears.

Frequently asked questions

Is PRN De3 worth the premium?

It offers the highest EPA+DHA dose in this comparison, rTG form, vitamin D3 and unusually specific Canadian dry-eye claims. Whether those differences justify the price depends on response, budget and professional advice.

Which has the fewest capsules?

Blink uses one daily but is not an omega-3 formula. Among compared omega products, I-VU uses two; PRN and Systane use three; NutraSea uses four.

Can I combine two products?

Do not stack them without reviewing total EPA, DHA, vitamin D and bleeding risk with a pharmacist or physician.

Sources

• Current EyeDropShop Canada product pages for PRN De3, I-VU Omega-3 Plus, NutraSea Dry Eye Soft Gels, Systane Omega-3 and Blink NutriTears, accessed July 2026.
• Health Canada NPN 80101489
• Epitropoulos et al., 2016

Product details may change. Check the current Canadian label and consult a healthcare professional.